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CHALLENGING CASES IN RETINAL VEIN OCCLUSION
 

Diana V. Do, MD

OVERVIEW

The retina specialty is morphing at extraordinary rates and is mainly being driven by the large-scale research efforts leading to new therapeutic strategies and several candidates in the clinical development pipeline. Results from 5 phase III studies on retinal vein occlusion (RVO) were recently announced. Namely, the National Institutes of Health’s SCORE (Standard Care vs Corticosteroid for RVO) study, 2 studies using dexamethazone intravitreal implant, the BRAVO (Efficacy and Safety of Ranibizumab Injection in Patients with Macular Edema Secondary to Branch RVO) trial, and the CRUISE (Efficacy and Safety of Ranibizumab Injection in Patients with Macular Edema Secondary to Central RVO) trial. Retina specialists treating patients with RVO have more therapeutic options, but are faced with a new dilemma: What treatment should I use? Lacking comparative, head-to-head data, the influx of information from clinical trials can be misleading. In order for clinicians to effectively treat patients with RVO, the educational gap between the most recent clinical research and results and then comparing and disseminating those results to clinicians must be filled. This CME activity is designed to help retina specialists aggregate, interpret, and apply the new data to their clinical practice.

GOAL

To provide retinal specialists with up-to-date information on the management of RVO.

INTENDED AUDIENCE

This activity is designed for retinal specialists. No prerequisites required.

LEARNING OBJECTIVE

After completing this activity, the participant will demonstrate the ability to:

  • DISCUSS the results of the latest clinical trials for the management of RVOs.
  • ASSESS the safety and efficacy of ophthalmic steroid preparations.

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

ACCREDITATION STATEMENTS

The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENTS

The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

The estimated time to complete this activity: 30 minutes.

Release date: July 15, 2010. Expiration date: July 15, 2012.

HOW TO RECEIVE CREDIT OR CONTACT HOURS

The following interactive case activity consists of 3 sections: a pre-test, an interactive case with decision points, and a CME post-test with an evaluation. All 3 sections must be completed to receive CME credit. A certificate of participation will be available online immediately following successful completion of the module.

FULL DISCLOSURE POLICY AFFECTING CME ACTIVITIES

As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine to require the disclosure of the existence of any relevant financial interest or any other relationship a faculty member or a provider has with the manufacturer(s) of any commercial product(s) discussed in an educational presentation. The Course Director and Participating Faculty reported the following:

Quan Dong Nguyen, MD, MSc (Chair)
Associate Professor of Ophthalmology
Diseases of the Retina and Vitreous, and Uveitis
Wilmer Eye Institute
Johns Hopkins University School of Medicine
Baltimore, Maryland

Diana V. Do, MD
Assistant Professor of Ophthalmology
Assistant Head, Retina Fellowship Committee
Retina Division
Wilmer Ophthalmological Institute
The Johns Hopkins University School of Medicine
Baltimore, Maryland

Participating Faculty Disclosures
Dr Do reports serving as a principal investigator for grants/research support for Genentech Inc, Heidelberg, and Regeneron Pharmaceuticals; and serving as a consultant for Bausch & Lomb, Incorporated and Santen Pharmaceutical Co, Ltd.

Planner Disclosures
Dr Nguyen reports serving as a principal investigator on grants from Genentech, Inc, Heidelberg, Lux Biosciences, Inc, MacuSight, Inc, Novartis, and Regeneron Pharmaceuticals, Inc; and serving as a consultant for Bausch & Lomb, Incorporated and Santen Pharmaceutical Co, Ltd.

Dr Do reports serving as a principal investigator for grants/research support for Genentech Inc, Heidelberg, and Regeneron Pharmaceuticals, Inc; and serving as a consultant for Bausch & Lomb Incorporated.

No other planners have indicated that they have any financial interests or relationships with a commercial entity.

Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution that receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

OFF-LABEL PRODUCT DISCUSSION

No faculty member has indicated that their presentation will include information on off-label products.

DISCLAIMER

The opinions and recommendations expressed by faculty and other experts whose input is included in this activity are their own. This activity is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format, design, and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings, and adverse effects before administering pharmacologic therapy to patients.

INTERNET CME POLICY

The Office of Continuing Medical Education (CME) at the Johns Hopkins University School of Medicine is committed to protect the privacy of its members and customers. Johns Hopkins University SOM CME maintains its Internet site as an information resource and service for physicians, other health professionals, and the public. Continuing Medical Education at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet based activity. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine’s CME activity. CME collects only the information necessary to provide you with the services that you request.

Supported by an educational grant from Allergan, Inc.

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