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THE MAGNITUDE OF OCULAR SURFACE DISEASE AND EVIDENCE-BASED TREATMENT OPTIONS

Presented by the Johns Hopkins University School of Medicine.

This educational activity is supported by an educational grant from Allergan Inc.

GOAL

To provide eye care professionals, including ophthalmologists and optometrists, with up-to-date information on the treatment and management of dry eye disease.

INTENDED AUDIENCE

This activity is designed for eye care professionals, including ophthalmologists and optometrists. No prerequisites required.

LEARNING OBJECTIVE

After completing this activity, the participant will demonstrate the ability to:

  • Recognize the importance of early diagnosis and treatment of dry eye disease based on the presence of comorbid conditions and/or risk factors.
  • ANALYZE the role of inflammatory processes in the development of dry eye disease.
  • DESCRIBE the impact of dry eye disease on the quality of life and productivity of patients.
  • Evaluate recent guidelines and clinical evidence regarding the diagnosis, classification, and management of patients with dry eye disease.
  • ASSESS the safety and efficacy of various treatment strategies in deterring disease progression for patients with dry eye disease.

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

ACCREDITATION STATEMENT

The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 2 AMA PRA Category I Credit(s)™ Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The estimated time to complete this educational activity: 2 hours.

Release date: October 15, 2012. Expiration date: November 30, 2014.

HOW TO CLAIM CREDIT

Please complete a brief pre-assessment before continuing with the monograph. After reading this monograph, participants may receive credit by completing the CME test and evaluation online, and receiving a score of 70% or higher.

Faculty
Full Disclosure Policy Affecting CME Activities:
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. The following relationships have been reported for this activity:

COURSE DIRECTOR
Esen K. Akpek, MD

Associate Professor of Ophthalmology
Director of the Ocular Surface Disease and Dry Eye Clinic
Associate Director of the Johns Hopkins Jerome L. Greene Sjögren's Syndrome Center
Wilmer Eye Institute
Johns Hopkins University School of Medicine
Baltimore, Maryland

PARTICIPATING FACULTY
Penny A. Asbell, MD, FACS, MBA

Professor of Ophthalmology
Director of Cornea and Refractive Services
Director of Clinical and Research Cornea Fellowships
Department of Ophthalmology
Mount Sinai School of Medicine
New York, New York

David B. Glasser, MD
Assistant Professor of Ophthalmology
Johns Hopkins University School of Medicine
Patapsco Eye MDs, LLC
Columbia, Maryland

Peter J. McDonnell, MD (Planner)
William Holland Wilmer Professor of Ophthalmology
Director, Wilmer Eye Institute
Johns Hopkins University School of Medicine
Baltimore, Maryland

Stephen C. Pflugfelder, MD
Professor of Ophthalmology
The James and Margaret Elkins Chair
Department of Ophthalmology
Cullen Eye Institute
Baylor College of Medicine
Houston, Texas

Debra A. Schaumberg, ScD, OD, MPH (Planner)
Associate Epidemiologist and Director,
Ophthalmic Epidemiology
Division of Preventive Medicine,
Brigham and Women’s Hospital
Associate Professor of Medicine and Ophthalmology
Harvard Medical School
Boston, Massachusetts

Participating Faculty Disclosures
Dr Akpek reports receiving grants/research support from Alcon Laboratories and Allergan, Inc. Dr McDonnell reports serving as a consultant for Advanced Medical Optics, Alcon Laboratories, and Allergan, Inc. Dr Schaumberg reports receiving a research grant from Pfizer Inc; serving as a consultant for Alcon Laboratories, Allergan, Inc, Eleven Biotherapeutics, Inspire Pharmaceuticals, Inc, Mimetogen Corporation, Pfizer Inc, Resolvyx Pharmaceuticals, Santen Corporation, and SARcode Corporation; serving as a scientific advisory board member for Mimetogen Corporation and SARcode Corporation; and having ownership interests in Mimetogen Corporation and TearLab. No other planners have indicated that they have any financial interests or relationships with a commercial entity.

Planner Disclosures
Dr Akpek reports receiving grants/research support from Alcon Laboratories and Allergan, Inc.

Dr McDonnell reports serving as a consultant for Advanced Medical Optics, Alcon Laboratories, and Allergan, Inc.

Dr Schaumberg reports receiving a research grant from Pfizer Inc; serving as a consultant for Alcon Laboratories, Allergan, Inc, Eleven Biotherapeutics, Inspire Pharmaceuticals, Inc, Mimetogen Corporation, Pfizer Inc, Resolvyx Pharmaceuticals, Santen Corporation, and SARcode Corporation; serving as a scientific advisory board member for Mimetogen Corporation and SARcode Corporation; and having ownership interests in Mimetogen Corporation and TearLab.

No other planners have indicated that they have any financial interests or relationships with a commercial entity.

Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution that receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).


Off-Label Product Discussion: The following faculty members have disclosed that their presentation will reference unlabeled/unapproved use of drugs or products:
Dr Akpek: topical steroids and cyclosporine.
Dr Glasser: corticosteroids (prednisolone, loteprednol, fluoromethalone, dexamethasone) and antibiotics (doxycycline, tetracycline, minocycline, azithromycin, erythromycin) for treatment of dry eye disease.
Dr McDonnell: hyaluronic acid-containing drops; these are available over the counter in the United States for artificial tears for dry eye, but hyaluronic acid is not specifically US Food and Drug Administration approved for dry eye.

DISCLAIMER
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.
INTERNET CME POLICY
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Confidentiality Disclaimer for CME Activity Participant
I certify that I am participating in a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am attending in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the "Privacy Regulations"). Protected health information is information about a person's health or treatment that identifies the person. I also understand that while I am participating in this capacity I will be treated as a temporary member of Johns Hopkins for purposes of the Privacy Regulations only.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.

“The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only.”

For CME Questions, please contact the CME Office (410) 955-2959 or e-mail cmenet@jhmi.edu.


Johns Hopkins University School of Medicine
Office of Continuing Medical Education
Turner 20/720 Rutland Avenue
Baltimore, Maryland 21205-2195
Reviewed & Approved by: General Counsel, Johns Hopkins Medicine (Updated 4/09)
HARDWARE & SOFTWARE REQUIREMENTS
Pentium 800 processor or greater, Windows 98/NT/200/XP or Mac OS 9/X or later, Microsoft Internet Explorer, Safari, Firefox, Windows Media Player 9.0 or later Flash player, 128 MB of RAM Monitor settings: High color at 800 x 600 pixels, Sound card and speakers, Adobe Acrobat Reader.
ACTIVITY
Instructions
The following activity consists of 3 sections: an unaccredited pre-test, a monograph, and a CME post-test and evaluation. All 3 sections must be completed to receive CME credit.

Pre-Test

Overview
The Magnitude of Ocular Surface Disease and Evidence-Based Treatment Options


Proceedings
Epidemiology of Dry Eye Disease and the Patient’s Perspective

Debra A. Schaumberg, ScD, OD, MPH

Dry Eye: An Underrecognized and Undertreated Disease
Peter J. McDonnell, MD

Diagnostic Modalities
Stephen C. Pflugfelder, MD

Post-Test
procced to pretest
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