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EXPANDING HORIZONS IN THE TREATMENT OF DIABETIC MACULAR EDEMA

Presented by the Johns Hopkins University School of Medicine.

This educational activity is supported by an educational grant from Alimera Sciences.

GOAL

The goal of this activity is to provide retina specialists and comprehensive ophthalmologists with the most up-to-date clinical knowledge and strategies for the optimal treatment and management of patients with diabetic macular edema (DME).

TARGET AUDIENCE

This activity is designed for retina specialists and comprehensive ophthalmologists who manage patients with DME. There are no prerequisites.

LEARNING OBJECTIVES

After participating in this activity, the participant should be able to:

  • DISCUSS the benefits and best use of anti-VEGF injections for DME and distinguish patients with an optimal response from those with a suboptimal response to anti-VEGF injections.
  • COMPARE the different approaches to intraocular steroid delivery and their potential benefits in the treatment of DME.
  • RECOGNIZE the potential risks of intraocular steroids with an in-depth look at the risk of increased intraocular pressure.
  • COMPARE how the benefits and risks may vary among different patients with DME with various corticosteroid formulations and anti-VEGF agents.

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

ACCREDITATION STATEMENT

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

CREDIT DESIGNATION STATEMENT

The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 2 AMA PRA Category I Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The estimated time to complete this educational activity: 2 hours.

After reading this monograph, participants may receive credit by completing the CME test, evaluation, and receiving a score of 70% or higher.

Release date: November 1, 2015. Expiration date: November 1, 2017.

PARTICIPATING FACULTY
Peter A. Campochiaro, MD (Course Director)
George S. and Dolores Dore Eccles Professor of Ophthalmology and Neuroscience
Professor of Ophthalmology
Johns Hopkins Wilmer Eye Institute
Baltimore, Maryland

Pravin U. Dugel, MD
Managing Partner
Retinal Consultants of Arizona, LTD
Retinal Research Institute, LLC
Phoenix, Arizona

Clinical Professor
USC Eye Institute
Keck School of Medicine
University of Southern California
Los Angeles, California

Alexander M. Eaton, MD
Founder and Medical Director
Retina Health Center, PL
Fort Myers, Florida

Richard K. Parrish II, MD
Edward W. D. Norton, MD Chair in Ophthalmology
Professor
Associate Dean for Graduate Medical Education
Director – Glaucoma Service
Bascom Palmer Eye Institute
University of Miami Miller School of Medicine
Designated Institutional Official - Jackson Health System/Jackson Memorial Hospital
Miami, Florida
HOW TO CLAIM CREDIT

Please complete a brief pre-assessment before continuing with the monograph. After reading this monograph, participants may receive credit by completing the CME test, evaluation, and receiving a score of 70% or higher. Certificates can be printed immediately online.

Faculty
Full Disclosure Policy Affecting CME Activities:
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine to require the disclosure of the existence of any relevant financial interest or any other relationship a faculty member or a sponsor has with the manufacturer(s) of any commercial product(s) discussed in an educational presentation. The Course Director, Planners, and Participating Faculty reported the following:

Participating Faculty Disclosures
Dr Campochiaro reports receiving grants/research support from AbbVie Inc, Allergan Inc, Genentech Inc, Genzyme Corporation, GlaxoSmithKline, Oxford BioMedica, Regeneron Pharmaceuticals Inc, and Roche; serving as a consultant for Advanced Cell Technology, Aerpio Therapeutics, AGTC, Akebia, Alimera Sciences, Allegro Ophthalmics LLC, Therapeutics, AsclepiX Therapeutics LLC, Eleven Biotherapeutics, Genentech Inc, Interxon, Kala Pharmaceuticals Inc, Regeneron Pharmaceuticals Inc, and RXi Pharmaceuticals; and reports receiving equity/royalties from GrayBug Inc.

Dr Eaton reports receiving grants/research support from Allergan Inc, Genentech Inc, and Regeneron Pharmaceuticals Inc; and serving as a consultant for and having ownership interest in Alimera Sciences.

Planner Disclosures
Dr Campochiaro reports receiving grants/research support from AbbVie Inc, Allergan, Inc, Genentech, Inc, Genzyme Corporation, GlaxoSmithKline, Oxford BioMedica, Regeneron Pharmaceuticals, Inc, and Roche; serving as a consultant for Advanced Cell Technology, Aerpio Therapeutics, AGTC, Akebia Therapeutics, Alimera Sciences, Allegro Ophthalmics LLC, AsclepiX Therapeutics LLC, Genentech Inc, Interxon, Kala Pharmaceuticals Inc, Regeneron Pharmaceuticals Inc, and RXi Pharmaceuticals; and reports receiving equity/royalties from GrayBug Inc.

No other planners have indicated that they have any financial interests or relationships with a commercial entity.

Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution that receives the grant, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

Off-Label Product Discussion
The following faculty have disclosed that their presentation will reference unlabeled/unapproved use of drugs or products:

Dr Campochiaro—bevacizumab.
Dr Eaton—bevacizumab and triamcinolone.

DISCLAIMER

The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

INTERNET CME POLICY

The Office of Continuing Medical Education (CME) at the Johns Hopkins University School of Medicine is committed to protect the privacy of its members and customers. Johns Hopkins University SOM CME maintains its Internet site as an information resource and service for physicians, other health professionals, and the public. Continuing Medical Education at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet based activity. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine’s CME activity. CME collects only the information necessary to provide you with the services that you request.

Confidentiality Disclaimer for CME Activity Participant

I certify that I am attending a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am attending in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the "Privacy Regulations"). Protected health information is information about a person's health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (eg, Facebook, Twitter, etc), in any electronic messaging program or through any portable electronic device.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.

“The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only.”

For CME Questions, please contact the CME Office at 410-955-2959 or e-mail cmenet@jhmi.edu. For CME Certificates, please call 410-502-9634.

Johns Hopkins University School of Medicine Office of Continuing Medical Education
Turner 20/720 Rutland Avenue
Baltimore, Maryland
21205-2195

Reviewed & Approved by: General Counsel, Johns Hopkins Medicine (4/1/03) (Updated 4/09 and 3/14)

HARDWARE & SOFTWARE REQUIREMENTS

Pentium 800 processor or greater, Windows 98/NT/200/XP or Mac OS 9/X or later, Microsoft Internet Explorer, Safari, Firefox, Windows Media Player 9.0 or later Flash player, 128 MB of RAM Monitor settings: High color at 800 x 600 pixels, Sound card and speakers, Adobe Acrobat Reader.

ACTIVITY

Instructions
The following activity consists of 3 sections: an unaccredited pre-test, a monograph, and a CME post-test and evaluation. All 3 sections must be completed to receive CME credit.


Pre-Test

REVIEW ARTICLES
Is Suppression of VEGF Alone Sufficient for Management of All DME?
Pravin U. Dugel, MD

Corticosteroid-Induced Increase in Intraocular Pressure: How Big of a Problem Is It?
Richard K. Parrish II, MD

CASE STUDIES
Making Sense of Treatment Options for Diabetic Macular Edema: Case Studies
Alexander M. Eaton, MD

Post-Test
procced to pretest
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